Microsoft article How to open Excel files in separate windows in Windows 7 explains how to open Excel files in separate instances of Excel, but this doesn’t work in Windows 10 systems. There is an additional step needed to make it work in Windows 10.
The additional step is to delete the value named "Command", in the right-pane of this key:
Note: Do not accidentally delete the "Command" subkey. You need to delete or rename the multi-string value (REG_MULTI_SZ) named "Command", in the right pane.
Make Excel Files Open in New Window (REG File)
Download excel-2010-new-window.zip, unzip and extract the REG files to a folder. Double-click to run it.
There is also an "undo" file included, in case you want to restore the default settings.
REG File Contents
Windows Registry Editor Version 5.00 [-HKEY_CLASSES_ROOT\Excel.Sheet.8\shell\Open] [HKEY_CLASSES_ROOT\Excel.Sheet.8\shell\Open] @="&Open" [HKEY_CLASSES_ROOT\Excel.Sheet.8\shell\Open\command] @="\"C:\\Program Files (x86)\\Microsoft Office\\Office14\\EXCEL.EXE\" \"%1\"" [-HKEY_CLASSES_ROOT\Excel.Sheet.12\shell\Open] [HKEY_CLASSES_ROOT\Excel.Sheet.12\shell\Open] @="&Open" [HKEY_CLASSES_ROOT\Excel.Sheet.8\shell\Open\command] @="\"C:\\Program Files (x86)\\Microsoft Office\\Office14\\EXCEL.EXE\" \"%1\""
Hope that helps!
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About the author
Ramesh Srinivasan founded Winhelponline.com back in 2005. He is passionate about Microsoft technologies and he has been a Microsoft Most Valuable Professional (MVP) for 10 consecutive years from 2003 to 2012.