Earlier we saw how to add and use the Go To Registry Key Menu Extension in Internet Explorer. If you’re using Mozilla Firefox as the primary Web browser, there is a similar add-on available. The Open In RegEdit add-on (by Nio Hashi) for Mozilla Firefox opens registry keys directly from the webpage using the Registry Editor.
The Open In RegEdit add-on for Mozilla Firefox works by setting the LastKey registry value and then opening the Registry Editor (regedit.exe). Note that we’ve covered the Regedit – LastKey method previously.
There is a drawback of using this method. If Registry Editor is already open, focus is not shifted from the existing registry branch. For this reason, we used the RegJump Utility from Windows Sysinternals for the Go To Registry Key Menu Extension for Internet Explorer.
Open In RegEdit Add-on for Firefox
Start Mozilla Firefox and navigate to Open In RegEdit add-on page. Click the Add to Firefox button and install the add-on.
Open a new instance of Mozilla Firefox and navigate to a Web page that contains information about modifying the registry. Select the text (registry key), right-click and choose Open In Regedit. Registry Editor will open directly to the selected key.

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Why not just have the Addon close RegEdit, change the RegEdit – LastKey value, the reopen RegEdit?