The Disk Defragmenter in Windows Vista is scheduled to run on every Wednesday at 1:00 AM. This article tells you how to disable the schedule (in case you've installed a third-party defragmenter), or modify the schedule accordingly.
Click Start, type dfrgui.exe and press {ENTER}. When you are prompted for an administrator password or confirmation, type the password or provide confirmation. To disable defragmenter schedule, uncheck the following option:
Run on a schedule (recommended)
Click OK
In case you want to modify the defragmenter schedule, click the Modify schedule... button, and select the frequency, time in the resulting dialog.